Pharmacological potential of ruzu Herbal bitter in an alloxan-induced wistar albino rats was evaluated using standard methods. Group A received 5ml of ruzu herbal bitters, group B received 2.5ml of ruzu herbal bitters, group C received 1.25 ml of ruzu herbal bitters, group D received 0.625ml of ruzu herbal bitters, group E received 250mg of diabenesse which served as the positive control and group F received 1ml of distilled water which served as a normal control. The antimicrobial activity of Ruzu bitters significantly (P<0.05) increased in Nesseria gonorrhea when compared with Ciprofloxacin while Ciprofloxacin showed a significant (P<0.05) increase in Pretous mirabilis and Klebsielle pneumonia when compared with ruzu herbal bitter. The blood glucose level showed a significant (P<0.05) increase in rats administered with 5 ml, 2.5 ml and 0.625 ml of ruzu herbal bitter on day 5 when compared with positive and normal controls where as rats administered 1.25 ml of ruzu herbal bitter showed no significant difference when compared to positive and negative controls. This showed that Ruzu herbal bitter possess antimicrobial and hyperglycaemic effect.