The names psoriasis seemingly emerged from the greek word ‘psora’ meaning ‘itch’. The aetiology of psoriasis is unknown. The theory of nervous origin has been given the best substantiation. According to this theory psoriasis is caused by the disturbances in the function of nervous system. In the present study, we used the Panchakarma as an ayurvedic treatment for the management of Psoriasis disease. The selection was made based on the various sign and symptoms indicative of this disease. We observed a time dependent improvement in patients with the sign and symptoms of Psoriasis disease.