Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2012 Vol: 4 Issue: 4

Evaluation of Ocimum sanctum and Ocimum basillicum Mucilage- As a Pharmaceutical Excipient


In recent year, limited choice of excipients with all the good qualities attributes and presently available in the market can make formulation design and Excipients selection challenging. Thus the aim of this study was to isolate and evaluate Pharmaceutical Excipient from the seed of Ocimum sanctum and Ocimum basillicum which can be useful for designing new formulations. The coarse powder of both Ocimum sanctum and Ocimum basillicum was defatted by using Petroleum ether and that defatted seeds were activated in hot air oven. The activated seeds are soaked in 6th part of chloroform water and filtered. To the filtrate an equal volume of alcohol (95%) was added to precipitate the excipient. The resultant excipients were evaluated for physicochemical properties, water absorption capacity, phytochemical test etc. The isolated excipients having neutral pH with slight solubility in water which produces a stable suspension. The concentration of excipient was increased with decrease in the specific gravity of solution. The study shown that, the parameters evaluated for excipients was within the permissible limits. This information can be useful for designing new formulations or for modification of the conventional formulations.

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