Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 4

Evaluation of aqueous extract of Roots of Carica papaya on wound healing activity in albino Rats

Abstract

Wound is a general complication seen all over the world and plants are mostly considered as a primary remedy to heal wounds. Lot of research on medicinal plants is now on par with synthetic molecules for decades to heal wounds, though a smaller complication yet dangerous if left untreated. Traditionally plant materials are used to treat and heal wounds for several thousand years. All the Indian systems of medicine, Ayurveda, Siddha and Unani describe drugs of plant, mineral and animal origin to treat and heal wounds. Plants are given prime importance as they are easily available but scientific evidence for their wound healing activity is available for only few plant materials. The present study was aimed to evaluate the wound healing potential of aqueous extract of roots of carica papaya. It is a well known plant in Indian traditional medicine. On the basis of traditional use and literature references, this plant was selected for evaluation of wound healing potential. An aqueous extract of root was examined for wound healing activity at doses 200 mg/kg which was evaluated for its wound healing activity in albino rats using excision and incision wound models. Latex treated animals exhibit 89.40 % reduction in wound area when compared to controls which was 80.38 %. The extract treated wounds are found to epithelize faster as compared to controls. Significant (p<0.001) increase in granuloma breaking strength (578.99±0.96) was observed. The Framycetin sulphate cream (FSC) 1 % w/w was used as standard.

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