Evaluate antipyretic Activity of Alcoholic Extract of vitex negundo In PGE1 induced pyrexia in Albino rats. Vitex negundo is generally known as Negundo in India. It is also known as the five-leaved chaste tree, is a large aromatic shrub with quadrangular, densely whitish, tomentose branch lets. It is widely used in folk medicine, particularly in South and Southeast Asia. It belongs to family Verbanaceae and is found throughout India. Vitex negundo has been used for various medicinal purposes in Ayurveda and Unani systems of medicine. The leaves and whole plant is used as an anti-inflammatory, antiseptic, antipyretic and diuretic. Antipyretic activity of leaves of vitex negundo is studied in brewer’s yeast induced pyrexia models. Our study is to evaluate antipyretic activity of alcohol extract of vitex negundo in PGE1 induced hyperpyrexia model in albino rats