In present study, a series of chalconesemicarbazones was synthesized and evaluated for their anti-phlogistic (anti-inflammatory) activities. Most of the compounds were found to be potent anti-phlogistic agent in formalin induced paw edema and cotton pellet induced granuloma in rats. Based on the results of an anti-inflammatory study, 1-[1-(2-hydroxyphenyl)-3-(2- hydroxyphenyl)allylidene]-4-(2-methylphenyl) semicarbazide (CS-6) was the most active compound. It was found that hydroxyl substituted chalconesemicarbazones were potent antiphlogistic agents and unsubstituted compound 1-[1-(2-hydroxyphenyl)-3-phenylallylidene]-4-(2- methylphenyl)semicarbazide (CS-1) and 1-[1-(2-hydroxyphenyl)-3-phenylallylidene]-4-(4- methylphenyl)semicarbazide (CS-2) showed very less activity.