Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2014 Vol: 6 Issue: 5

Evaluation of anti-cholesteremic and anti-lipidemic activity of seed extract of Achyranthes aspera in diet induced hyperlipidemia model in rats


The present study was carried out to evaluate the anti-cholesteremic and Anti-lipidemic activity of methanolic seed extract of Achyranthes aspera using Diet-induced hyperlipidemia model in Wistar albino rats. Albino Wistar rats of either sex weighing in between 200-350 gms were divided into 6 groups containing 6 animals in each group. All the groups received cholesterol (400mg/kg b.w. in 5ml coconut oil p.o) except saline control for 2 weeks and were tested orally at a dose of 150, 300 and 600 mg/kg body weight. The extract (300 and 600 mg/kg) showed significant (P<0.05) reduction in total serum cholesterol and lipid levels compared to vehicle control group. The serum Total cholesterol, Triglyceride, HDL, VLDL and LDL levels were analyzed. This present study proved that methanolic seed extract of Achyranthes aspera shows significant Anticholesteremic and Antilipidemic activity against the Diet induced hyperlipidemia model by reducing the serum TC, TG, VLDL, LDL levels and increasing HDL level..