Hyperlipidemia, hyperlipoproteinemia, dyslipidemia or hyperlipidemia is the presence of raised or abnormal levels of lipids and/or lipoproteins in the blood. Plants represent a vast source of potentially useful dietary supplements for improving blood glucose control and preventing long term complications. The present work is aimed at exploring the antibacterial, antioxidant and anti-hyperlipidemic activities of leaf extracts of Psidium guajava. The antibacterial activity of the extract was tested against various bacterial pathogens by agar well diffusion method. All the extracts have shown good antibacterial activity against Staphylococcus aureus and Klebsiella pneumoniae. Petroleum ether extract of the plant showed least activity against K. pneumoniae. The ethyl acetate, petroleum ether and methanol extracts were studied for their antioxidant activities at different concentrations (20, 40, 60, 80 and 100 μg/ml) using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay. The free radical scavenging potential of the methanol extract exhibited the maximum activity of 81.24% in 100 μg/ml concentration. The lipid peroxidation inhibitory potential of the methanolic extract showed the maximum inhibitory activity of 94.32 %. By virtue of its antioxidant activity the methanolic extracts of P. guajava may show anti-hyperlipidemic activity.