Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 3

Evaluation of antibacterial activity of leaf and stem extracts of Combretum calobotrys


Antibacterial activity of the extracts and fractions of leaf and stem of Combretum calobotrys Engl. & Diels (Combretaceae) against clinical isolates of Bacillus subtilis, Pseudomonas aeruginosa, Salmonella paratyphi, Eschericia coli, Staphylococcus aureus and Klebsiella pneumonia were evaluated using the agar diffusion method. Results showed that with the exception of the stem methanol fraction, all the extracts and fractions, elicited antibacterial activity. The leaf methanol fraction had minimum inhibitory concentration (MIC) of 0.32 mg/ml against K. pneumoniae while the stem ethylacetate fraction had MIC of 0.46 and 0.78 mg/ml against P. aeruginosa and S. aureus respectively. The results justify the ethnomedicinal use of C. calobotrys in Southeastern Nigerian to manage bacterial infections

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