The aim of the present study was to evaluate and compare the antimicrobial activity of Bougainvillea glabra ‘Snow White’ leaves extract with Bougainvillea glabra ‘Choicy’ leaves extract. Bougainvillea glabra ‘Snow White’ is a cultivated variety of Bougainvillea glabra ‘Choicy’ which have white bracts with greenish veins. Antimicrobial activity of different solvent extracts of these plant leaves were tested against Gram positive and Gram negative bacterial strains by observing the zone of inhibition. Antimicrobial activity was done by disc diffusion method at a concentration of 500 μg/disc of the extract, using ofloxacin (5μg/disc) as the standard. The bacterial strains used in the study were Staphycococcus aureus, Bacillus subtilis, Escherichia coli, Salmonella typhii, Klebsiella pneumoniae, Proteus vulgaris, and Vibrio cholerae. Hydroalcoholic extract was more active against all bacteria. Bougainvillea glabra ‘snow white’ was not effective against Bacillus subtilis and Micrococcus leuteus while B. glabra ‘choicy’ was not effective against Proteus vulgaris.