Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 1

Evaluation of anti hyperglycaemic activity of Zingiber officinale(Ginger) in albino rats


Zingiber officinale (commonly known as ginger) is widely used in traditional medicine. The juice of Z. Officinale has shown hypoglycemic activity in STZ induced diabetic rats. The present study was designed to compare the anti hyperglycemic activity of juice of Z. Officinale with standard glibenclamide and metformin in alloxan induced diabetic rats. 30 albino rats were randomly divided into 5 equal groups. Four groups of six animals each were induced diabetes by giving alloxan. Group I: Normal control, Group II: Diabetic control receiving normal saline (0.5 ml), Group III: Standard control 1 receiving glibenclamide (5 mg/kg body weight), Group IV: Standard control 2 receiving metformin (10 mg/kg body weight) and Group V: Test group receiving Z. officinale juice (4 ml/kg body weight). Fasting blood sugar level was estimated on day 1,3,7,14,21,28,35 and 42 from rat tail vein using glucometer. Data was statistically analyzed by New Mann Keul’s Post Hoc test and ANOVA. Fresh juice of Z. Officinale produced a time dependent decrease in blood glucose level significantly compared to both glibenclamide and metformin. The earlier study has showed Z.officinale juice increases insulin sensitivity. However this study shows hypoglycemic action inspite of insulin depletion by alloxan and additional non insulin related hypoglycemic action could be inferred. Further studies are needed to explore this property.

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