This study was designed to formulate and develop the cefixime trihydrate 100 mg oral suspension using Anogeissus Leiocarpus gum as suspending agent, and its in-vitro quality evaluation. Dry direct mixing method was adopted for preparation of suspensions using different excipients namely; sodium benzoate, strawberry flavour, sucrose, areosil and Anogeissus Leiocarpus gum. The suspensions were evaluated for pH, density, sedimentation, rheological assessment; also, suspensions were subjected to assay in vitro studies. The formula was satisfactory per cefixime trihydrate 100 mg oral suspension properties and complied with the USP pharmacopoeia standard requirements when compared with marketed products.