This study aimed to perform a literature review about Cotard's syndrome, or delusions of negations (as it is also called). Data collection was based on the following search websites: Science Direct, Web of Science, PsycINFO, Medline, PubMed, Lilacs and Scielo, without limit time between publications. All papers found in review literature, in total 297, were selected and analyzed. In according with results, it was possible to organize a general survey about this very rare syndrome, discussing their symptoms, probable etiology, neurochemical processes involved, clinical diagnosis and treatment. In addition, it was also possible to construct a list of the most commonly prescribed drugs by pshychiatrists, including per day dosage administered and the pharmacological class. In this view, it was observed among these most prescribed drugs, antidepressants represent the main class employed in treatment of these patients. After statistical analysis, it was observed the incidence of this syndrome in repoted cases, using sex and age as variables, showing a great incidence upon female individuos between 50 and 59 years old.