Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2012 Vol: 4 Issue: 6

Estimation of zaleplon by a new RP-HPLC method


A Simple, Sensitive and specific reverse phase high performance liquid chromatographic method has been developed for the determination of Zaleplon tablet Dosage Forms. Chromatographic separation was achieved on a Symmetry C8 (250×4.6 mm), 5.0 µm column with a 60:25:15mixture of 0.02M potassium dihydrogen phosphate w/v, acetonitrile v/v and methanol v/v as mobile phase, detection was at 240 nm. Response was a linear function of concentration in the range 2-0.01 µg/mL for Zaleplon. LOD and LOQ for Zaleplon were found 0.01 mg/L and 0.03 mg/L. Accuracy (recoveries 92-98%) and reproducibility were found to satisfactory.

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