Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 1

Enhancement of solubility and dissolution of poorly soluble drug: Ketoprofen as a model drug


The objective of the study was to formulate micro particles of a poorly soluble drug Ketoprofen with the aid of Chitosan in presence of salting out agents. Dissolution Studies were carried out in 0.1N HCl using USP type II dissolution apparatus. The effect of Chitosan in presence of salting out agent predominated drug dissolution rate with the increasing concentrations of chitosan. A decrease in dissolution rate can be explained based on the viscous gel formation by chitosan at higher concentration (above 0.4%). The fine and fluffy physical state of optimized formulation along with their porous and rough surface as supported by SEM photomicrographs might have contributed to the enhanced solubility and dissolution rate of ketoprofen. Accelerated stability studies were performed as per ICH guidelines.

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