Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Reviews: 2011 Vol: 3 Issue: 3

Ehler Danlos Syndrome: An Overview


Ehelr Danlos Syndrome is characterized in its most common form by hyperextensibility of the skin, hypermobility of joints often resulting in dislocations, and tissue fragility exemplified by easy bruising, atrophic scars following superficial injury, and premature rupture of membranes during pregnancy. Heterogeneity between the several clinical syndromes both complicates the diagnosis of EDS and makes accurate diagnosis imperative. It is caused by various abnormalities in the synthesis and metabolism of collagen (a component of the matrix) and other connective tissue proteins and its Signs vary widely based on which type of EDS the patient has. There is no cure for Ehlers Danlos Syndrome. The treatment is supportive and close monitoring of the cardiovascular system, physical therapy, occupational therapy, and orthopedic instruments (e.g., wheelchairs, bracing) may be helpful.

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