We investigated the effects of the extract of C. oxyacantha in rats by monitoring blood homeostasis and body weight as well as toxicity. Animals were treated daily with an oral dose of 100mg/kg body weight for 12 weeks. The powder of the plant was extracted in Soxhlet apparatus with methanol. Changes in hepatic enzymes levels were not observed in C. oxyacantha treated rats after 12 weeks of treatment. The serum cholesterol, triglycerides and glucose levels and the count of leukocytes and platelets decreased significantly by 15.5, 22, 16.5, 35 and 32%, compared to control values, respectively; while haematocrit and haemoglobin levels increased significantly by 6.4 and 17.4%, respectively. In parallel, significant slowdown of the body weight evolution was observed in C. oxyacantha treated animals comparatively to the animal control group. These results support the traditional use of C. oxyacantha as a treatment of the dyslipidemia and the hyperglycaemia, and related abnormalities; however, indicate a relative toxicity of this plant.