To explore the effects of Kangbingdu Oral Liquid (KOL) on immunological function of normal mice. The effects of the large,middle and small dosage KOL and Hornsey brand KOL were investigated on normal mice by macrophage percentage and index of phagocytosis,the formation of hemolysin and hemolytic plaque and lymphocyte transformation. Compared with physiological saline group,the large, middle and small dosage KOL group and Hornsey brand KOL group could significantly improve the macrophage percentage of normal mice abdominal cavity,the large,middle dosage KOL group and Hornsey brand KOL group could significantly improve the phagocytic index of normal mice abdominal cavity.The large,middle and small dosage KOL group and Hornsey brand KOL group could significantly promote the formation of hemolysin of normal mice,the large dosage KOL group and Hornsey brand KOL group could significantly promote the formation of hemolytic plaque,the middle and small dosage KOL group could significantly promote the formation of hemolytic plaque.The large,middle and small dosage KOL group and Hornsey brand KOL group could significantly improve the lymphocyte transformation of normal mice,the middle dosage KOL group had the strongest effect. KOL could enhance the immune function of normal mice.