Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2015 Vol: 7 Issue: 7

Effects of disintegrant pellets on Indapamide sustain release tablet formulated by reservoir technique


In this study tablets prepared by using three different types of pellets i.e. Indapamide drug pellets, Indapamide coated pellets and disintegrant pellets shows independent influence on the formulation. Drug release from reservoir pellets coated with ethyl cellulose and Eudragit RS 100 was depends on the thickness of coating and compaction pressure. Segregation is the problem, which can be minimizing by using disintegrant pellets in the formulation that gives the better understanding of formulation factors. HPMC K4M and MCC pH 101 were use as a binder in all formulations, PEG 400 as plasticizer, magnesium stearate and talc as lubricant. The percentage drug release of batch F3 was show 88.86 means 2.221 mg of Indapamide release in 12 h and all the physical evaluation results were within the prescribed limits. The metformin sustain release F3 batch showed non-Fickian diffusion kinetics