The purpose of study to shows the effect of Xenical drug and Green coffee on BMI and lipid profiles among Jordanian people. Methods 30 individuals with obese, age 30 years or older were recruited for participating in the study, divided into three groups each one 10 persons. Group 1 taken 120mg Xenical. Group 2 Green coffee 200 mg/day. Group 3 Xenical and Green coffee. All three groups are compare with control group 5person. All the groups and control allowed to take their routine diet only2000 thousand Calories per day . BMI and lipids level were measured at baseline starting day and after one month. Results showed reduction in the BMI in all groups control group,group2, group1 and group 3 respectively. Also all participates were showed decrease in blood glucose, cholesterol, triglyceride, and low-density lipoproteins (LDL) and increased in high-density lipoproteins (HDL). Conclusion Administration of green coffee showed lowering level FBG and lipids profile also BMI.