Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 3

Effect of Lovastatin on Lipoprotein Lipid Peroxidation and Antioxidant Status in Inflammation Induced Hyperlipidemic Rats

Abstract

Cardiovascular diseases (CVD) are the major contributor to the global burden of disease. Coronary heart disease, cerebrovascular disease, hypertension, artery disease, rheumatic heart disease, congenital heart disease and failure of heart came under the category of CVD. Epidemiological studies have suggested a link between atherosclerosis, infection and inflammation. Atherosclerosis is a multifaceted disease process with several different well defined risks factors, such as hypercholesterolemia, hypertension and diabetes. In this study we investigate the efficacy of hypolipidemic, anti-atherogenic and antioxidant agent Lovastatin by analyzing all the parameters in plasma, Total lipid, TC, TG, VLDL-C, LDL-C, non-HDL-C, MDA and Hepatic TG, TC as well as hepatic antioxidant enzymes (Catalase, Superoxide dismutase, Glutathione peroxidase and Glutathione reductase). All the plasma lipids parameters as well as hepatic antioxidant enzymes level were significantly increased/decreased in inflammation induced hyperlipidemic (IIH-C) rats. After 4-weeks administration of Lovastatin significantly restore the above altered parameters. In conclusion, Lovastatin may be useful in the prevention and treatment of inflammation induced hyperlipidemia, CVD and atherosclerosis.