Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 6

Effect of ethanolic extract of Allium sativum bulbs on Streptozotocin induced diabetic rats

Abstract

The hypoglycemic properties of the ethanolic extrac t of the bulbs of Allium sativum were evaluated in normoglycemic rats in order to scienti fic validate its traditional therapeutic use with the doses of 500 mg/kg body weight. The ethano lic extract of A. sativum bulbs reduced the blood glucose level by 49 % after two weeks treatme nt of albino rats respectively. Oral administration of the ethanolic extract of A. sativ um bulbs at dosed equivalent to 100, 250 and 500 mg/kg body weight produced significant (P<0.10) hypoglycemic effects in normal fasted animals after 7 days and 14 days respectively. The dose of extract reduced the blood concentration of the fasted normal rats from an ini tial mean value of 288.24 ± 7.48 at 0 day reduced blood glucose level 141.32 ± 10.61 at the e nd of 14 days. It is worthy to mentioned that animals treated with glibenclamide (500 μ g/kg) showed a significant reduced in the blood glucose level.