Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2016 Vol: 8 Issue: 7

Effect of D-/L-form ratio on properties and drug release behaviors of amorphous poly(D,L-lactide) microparticles

Abstract

In this study, the influence of the D-/L-form mole ratio of lactic acid on poly(D,L-lactide) (PDLLA) properties and its drug release behaviors were investigated and discussed. The PDLLAs were synthesized by ring-opening polymerization of DLLA monomers. The DLLA monomers with different D-/L-form ratios were prepared by polycondensation followed by a thermal decomposition processes for the D,L-/L-lactic acid mixtures. All the PDLLAs were complete amorphous for the D,L-/L-lactic acid mole ratios of 100/0-50/50. Indomethacin, a poorlywater soluble model drug was entrapped in the PDLLA microparticles. All drug-loaded PDLLA microparticles prepared by the oil-in-water emulsion solvent evaporation method were spherical in shape and had a smooth surface. In vitro drug release behaviors showed that the drug release from the PDLLA microparticles prepared with different D-/L-form ratios was similar. It is considered that the PDLLAs with a higher L-form ratio have the potential to be developed further as a lower-cost PDLLA for use in controlled release drug delivery applications