Sustained release delivery systems have shown to be of better significance in release rate for drug. The present work was an attempt to study the effect of different polymers like HPMC – K100M, HPMC – K15M, Chitosan, and Aloe mucilage on release of the sustained release tablets of the Glipizide. The formulations were prepared with the polymers in different ratios with the drug (drug: polymer, 1:6, 1:7, 1:8) by wet granulation method. Sustained release tablets of Glipizide which on oral administration prolongs its release thereby increasing bioavailability, diminishing side effects and enhanced patient compliance. The prepared formulations were evaluated with precompression parameters like bulk density, compressibility index, hausner’s ratio, angle of repose and postcompression parameters like weight variation, thickness, hardness, friability. In vitro drug release studies were carried out using USP XXIV dissolution apparatus type II at 50 rpm. The dissolution medium consisted of 900 ml of pH 7.4 phosphate buffer, maintained at 37+ 0.5 0 C. Among all the formulation the HPMC – K100M shows the better retarding of drug release from the Glipizide sustained release tablets.