Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2012 Vol: 4 Issue: 7

Effect of cellulose and non-cellulose polymers on ciprofloxacin extended release tablets


Sustained release delivery systems have shown to be of better significance in release rate for drugs [1] . The present study was an attempt to develop extended release ta blets of Ciprofloxain HCl which on oral administrat ion prolongs its release thereby increasing bioavailability, dim inishing side effects and enhanced patient complian ce. Ciprofloxacin HCl is used to treat a number of infe ctions including: infections of bones and joints, e ndocardiasis, gasteroenteritis, prostatitis, anthrax and chancroi d 5 . Ciprofloxacin extended release tablets were formu lated using polymers HPMC (K4M, K15M, K100M) and Carbopol 71G b y wet granulation technique [2] . The prepared formulations were evaluated with pre-compression pa rameters like bulk density, compressibility index, hausner ratio, angle of repose and post-compression paramet ers like weight variation, thickness, hardness, fri ability, in-vitro dissolution study. The in-vitro dissolution study o f formulation CE10 shows drug release within 24 hou rs