Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 5

Effect of astragalin on the activities of membrane bound enzymes on leadacetate toxicity in albino rats


In vivo effect oflead on membrane bound enzymes like Na+ and K+ ATPase, Ca2+ATPase, Mg2+ATPase, total ATPases were studied. on RBC membrane exposed to 90 days to a sublethal concentration (160 mg/kgb.wt/day) of lead. The activity of membrane bound enzymes in RBC membrane of lead acetate treated rats was found to be decreased as compared to those of control rats. Asignificant (p<0.05) increase in the enzyme activity was observed on treatment with astragalin on lead acetate supplementation as compared to those of the untreated induced fed rats.