A novel, safe, accurate, sensitive and economic Spectrophotometric method was developed by application of mixed hydrotropy using 2 M sodium acetate and 8 M urea solution (50:50% V/V) as hydrotropic solubilizing agent for the quantitative determination of poorly water-soluble pramipexole dihydrochloride (solubility:- 1.4 X 10-01 mg/ml in water) in tablet dosage form. The solubility of Pramipexole Dihydrochloride increases more than 46 times in mixed hydrotropic solution as compared to solubility in distilled water. Pramipexole dihydrochloride shows maximum absorbance at 262 nm. Sodium acetate, urea and other tablets excipents did not show any absorbance above 250 nm and thus no interference in the estimation was seen. Pramipexole dihydrochloride was obeyed Lambert Beer’s law in the concentration range of 15 to 75 μg/ml (r2= 0.9997) in mixed hydrotropic agent with mean recovery was found 98.35±0.55%. The percent concentration in marketed tablet formulation was found 97.52±1.65%. Parameters such as linearity, precision, accuracy, specificity and robustness were studied as reported in the International Conference on Harmonization guidelines. The relative standard deviations for three replicate measurements in five concentrations of samples were always less than 2%. So this method can successfully employ in the routine analysis of pramipexole dihydrochloride in bulk drug and tablet dosage forms.