Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2016 Vol: 8 Issue: 6

Dietary essential oil protects gastrointestinal tract against 1,2-dimethylhydrazine and dextran sodium sulfate induced ulcerative colitis associated colon carcinogenesis

Abstract

Colorectal cancer (CRC) is the third common malignancy and a major cause of morbidity and cancer-related death worldwide. Carvacrol is a dietary essential oil possesses several pharmacological effects such as antioxidant, antiinflammatory, anti-proliferative in experimental animal models. The present study is aimed to analyze the effect of carvacrol on matrix degrading lysosomal enzymes, collagen accumulation and glycoconjugate levels during 1, 2 dimethylhydrazine (DMH) plus dextran sodium sulfate (DSS) induced inflammation associated colon carcinogenesis. Ulcerative colitis associated colon cancer was developed in male Fischer rats (F344 rats) by three subcutaneous injection of DMH (40 mg/kg body wt) in the first week and free access to drinking water containing 1% DSS for next one week followed by 7-14 days of water as three cycles. Dietary supplementation of carvacrol was given before and after induction period through orally at a concentration of 50mg/kg body weight. The increased level of collagen deposition was observed by histopathological staining in DMH/DSS-induced rats were decreased upon carvacrol treatment. Furthermore, the increased activities of matrix degrading lysosomal enzymes in DMH/DSS-induced rats were regulated upon carvacrol supplementation. Carvacrol also reduced the mucus depletion due to ulcer in tumor bearing rats. In conclusion, Carvacrol may be act as a potent chemopreventive agent against experimental colon carcinogenesis.