Biochemical parameters such as blood sugar, alanine aminotransferase, albumin, bilirubin, anti-oxidant enzymes, aspartate aminotransferase, serum super oxide mutes (SOD), catalase (CAT) concentration, glutathion (GSH), malondialdhyde (MDA) cortisol hormone and interleukin-6 for three groups of Egyptian voluntary patients aged 18-60 years (mixture of males and females) have been monitored and investigated. The experiment included three groups as such: Group 1: Healthy control: served as healthy subjects and they did not show any clinical or biochemical disorders. Group 2: patients control with liver cirrhosis, and group 3: as patient with liver cirrhosis associated with diabetes mellitus (DM). The results showed that DM accelerates liver fibrosis and inflammation and giving rise to more severe liver failure and may potentiate the incidence of bacterial infections in cirrhotic patients which may associated with increased mortality.