Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2013 Vol: 5 Issue: 5

Development of fast dissolving tablets of losartan potassium using Kollidon CL-SF


The goal of this study was to formulate and evaluate fast dissolving tablets (FDTs) of Losartan potassium so as to overcome swallowing difficulties. The key to develop successful FDT formulations by the direct compression method is to select the right superdisintegrant and compatible excipients depending on FTIR and DSC studies. The FDTs were designed using superdisintegrant such as Kollidon CL-SF in different concentrations by direct compression technique. The FDT formulations were evaluated for physicochemical characteristics including powder flowability, appearance, thickness, uniformity of weight, hardness, friability, in-vitro disintegration time, wetting time, water absorption, content uniformity and in-vitro drug release studies. All the formulations showed satisfactory physicochemical characteristics with disintegration time less than three minutes. The selected formulations were subjected to short term stability studies at 40±2°C and 75±5% RH for a period of 3 months. Thus, this work helped in understanding the effect of formulation processing variables especially different concentrations of super disintegrating agent such as Kollidon CL-SF on the disintegration time.