A simple and sensitive extractive spectrophotometric method has been developed for the determination of copper (II) using [N - (o - hydroxy benzylidene) pyridine - 2 - amine] (NOHBPA) as an analytical reagent. NOHBPA has been synthesized and characterized by elemental and spectral analysis. NOHBPA forms reddish brown colour complex of copper (II) and extracts quantitatively (99.40%) into benzene from an aqueous solution of pH range 6.8 - 7.5. The benzene extract shows an intense peak at 540 nm (λ max). The system obeys Beer's law over the Cu (II) concentration range of 0.1 - 14 μg/ml. The sandell’s sensitivity and molar absorptivity for Cu - NOHBPA system is 0.0182 μgcm-2 and 3494.84 L mole-1cm-1 respectively. The composition of extracted species is found to be 1:2 (Cu: NOHBPA) by Job’s Continuous Variation and Mole Ratio Method. Interference by various ions has been studied. The proposed method has been successfully employed for the determination of Cu (II) in Pharmaceutical samples.