Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2011 Vol: 3 Issue: 6

Development of Domperidone: Polyethylene Glycol 6000 Fast Dissolving Tablets from Solid Dispersions Using Effervescent Method


Fast dissolving tablets of domperidone solid dispersions were prepared by effervescent method with a view to enhance patient compliance. Domperidone is water insoluble anti emetic drug, with problems of variable bioavailability and bio- inequivalence related to its poor water solubility. The purpose of present investigation to increase the dissolution rate of domperidone by developing domperidone fast dissolving tablets using domperidone solid dispersions, and to determine the influence of amount of superdisintegrant and effervescent materials on tablet disintegration. Differential scanning calorimetry, infrared spectroscopy and scanning electron microscopy were used to characterize the solid state of solid dispersions. Tablets were prepared by conventional direct compression method using Ac-Di-Sol (2-6%) as a superdisintegrant and mixture of sodium bicarbonate (6-18%) and citric acid (3-6%) was used as an effervescent material, along with directly compressible Mannitol to enhance mouth feel. In-vitro dispersion time of the formulation containing Ac-Di-Sol (6%) and mixture of sodium bicarbonate(18%) and citric acid(6%) was found to be 31 seconds and released 88% drug in 5 seconds, whereas marketed tablet released 58% drug in 30 min. Stability study indicated that there were no significant changes in tablet quality was observed.