Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2013 Vol: 5 Issue: 7

Development of Controlled Release Tablets of Nisoldipine with Improved Pharmaceutical Properties

Abstract

The present investigation was undertaken with an objective of formulating controlled release (CR) matrix tablets of Nisoldipine (NIS), an anti-hypertensive and anti-anginal drug based on the formation of inclusion complexes with β- Cyclodextrin (β-CD) & Hydroxy Propyl-β-Cyclodextrin (HP-β-CD) i.e., NIS-β-CD and NIS-HP-β-CD at 1:1 and 1:2 M ratios. Binary systems of NIS-CD were prepared by kneading method (KS) and physical mixtures (PM). KS exhibited superior dissolution properties when compared to PM, pure NIS and the improvement in dissolution rate values were in the order of KS > PM > pure NIS. The dissolution properties for NIS-CD binary systems were in the order of HP-β-CD > β-CD. These binary systems prepared by kneading technique were further compressed into tablets by direct compression process using Hydroxy Propyl Methyl Cellulose (HPMC K 100 LV) as drug release retardant and were evaluated for various physico-chemical/mechanical parameters. Formulation containing NISHP-β-CD 1:1M gave superior release 99.39 ± 0.53 % at th e end of 6 hrs when compared to NIS-β-CD (1:1M) and pure NIS formulations. The dissolution data was also evaluated for drug release kinetics and mechanism.