Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2011 Vol: 3 Issue: 1

Development, characterization and solubility study of solid dispersion of Valsartan


For a successful formulation, various formulation parameters that play a crucial role are aqueous solubility; stability at ambient temperature and humidity, photostability, compatibility with solvents and excipients etc Among all these, Solubility is the most important property for developing formulations. In the present study, an attempt was made to improve the solubility and dissolution rate using solid dispersion of a poorly soluble drug valsartan by using Soluplus as carrier material to enhance the solubility as well as dissolution rate. Five different formulations were prepared using hot melt extrusion technique in different ratios i.e., 1:1, 1:3, 1:5, 1:7, and 1:9. The formulations were further characterized by FTIR, DSC, and SEM analysis. The results of FTIR revealed that there exist no chemical interaction between the drug and the polymer. DSC studies showed that the drug was in amorphous state completely entrapped by the polymer. SEM studies showed the surface morphology of the solid dispersion. All the formulations showed a marked increase in the solubility behavior and improved drug release when tested for their Invitro studies. Formulation containing drug: polymer of 1:9 showed the best release with a cumulative release of 100%. Hence, it was concluded that soluplus as a carrier can be very well utilized to improve the solubility of poorly soluble drugs. ______________________________________________________________________________

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