Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2016 Vol: 8 Issue: 3

Development and validation of stability-indicating RP-HPLC method for estimation of Ziprasidone in bulk and their capsule dosage form

Abstract

A sensitive, simple, fast, accurate and precise reverse phase high performance liquid chromatographic (RP-HPLC) method has been developed for the estimation of ziprasidone hydrochloride (ZH) in bulk and pharmaceutical dosage forms. The method was developed to analyze by using agilent zorbax C-8 (4.6mm X 150mm, 5 μm) column, mobile phase consisting of methanol and potassium dihydrogen orthophosphate buffer at pH 3.0, the flow rate of 1.5 ml/min and detection wavelength 229 nm and eluted at 22.2 min. The linearity ranges were 25% to 150 % for Ziprasidone hydrochloride. Analytical method was validated according to the International conference on Hormonization (ICH) guidelines for various parameters like specificity, linearity, precision, accuracy, LOD, LOQ and system suitability. Validated method was applied to the commercially available pharmaceutical dosage forms and obtained the desired result. So the method can be successfully applied for routine analysis