Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 4

Development and Evaluation of Taste-Masked Rapid Dissolving Tablets of Cetrizine hydrochloride


Allergy is common problem among all age groups. Similarly difficulty in swallowing is common especially in elderly and pediatrics. Mouth dissolving tablets constitute an innovative dosage forms that overcome the problems of swallowing and provides a quick onset of action. The purpose of this study was to formulate and evaluate rapid dissolving tablet of cetrizine hydrochloride using camphor and menthol as sublimating agent. Tablets were prepared by sublimation technique. Six different formulations were prepared. The tablets were evaluated for hardness, uniformity of weight, friability, wetting time, disintegration time and in vitro drug release. The best formulation was selected on the basis of least wetting and disintegrating time and better drug release.