Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2013 Vol: 5 Issue: 3

Development and evaluation of mouth dissolving films of salbutamol sulfate


The present investigation was undertaken with the objective of formulating mouth dissolving films (MDFs) of the anti-asthmatic drug, Salbutamol Sulfate (SAL) to enhance convenience and compliance to the elderly and pediatric patients for better therapeutic efficacy. Film former, Hydroxypropyl Methylcellulose (HPMC) of different viscosity grades along with film modifier/solubilizing agents, polyvinyl pyrrolidone K30 (PVP K30) and sodium lauryl sulphate (SLS) were used to formulate MDFs. The MDFs were prepared by wet film applicator technique and were evaluated for in vitro dissolution characteristics, in vitro disintegration time, and their physico-mechanical properties. MDFs with 13% (w/w) of HPMC E5 gave better dissolution properties when compared to HPMC E15. MDFs with 0.04% (w/w) of SLS gave superior dissolution properties when compared to MDFs without SLS. MDFs with 0.04% (w/w) PVP did not peel off from glass plate and hence were excluded from study. Overall, MDFs showed good mechanical properties like tensile strength, folding endurance and % elongation and HPMC is an excellent film former for the preparation of MDFs.