This study was conducted to analysis various water samples of SEZ of Mambattu, Tada mandal, SPSR Nellore district and assess the possible impacts of such effluents on quality of open well water and surface water. A total of 10 samples including 5 from surface water (surrounding industries leather ,power, steel, electronics, chemical, matrices, etc.), and 5 from open well water of all bore wells in the vicinity of the SEZ were collected in November 2011, the samples in the SEZ of mambattu, the industry like leather, Power, Steel, Electronics, Chemicals, Matrices are located were analyzed for various physico chemical parameters like temperature, pH, EC,DO, Total Hardness, BOD,COD,TDS, Sulphates, Nitrates, Chloridres and heavy metals like Fe, Pb, Zn, Mn, Cd .The results were compared with US EPA and WHO standards for both surface and open well water collected from above said area. All physicochemical parameters are within the permissible limit except Fe concentrations which were found above the permissible limit.