In the present time the various diuretic drugs are being used in various combinations and formulations to treat the wide varieties of ailments related to cardiac problems and hypertension. Hydrochlorothiazide is a very important drug which is available in a no. of diuretic combinations. In this review we have represented a few HPLC methods for the determination of Hydrochlorothiazide and other drugs in its combination like amlodipine, telmisartan, candesartan, enalapril, methldopa, bisoprolol, valsartan, lisinopril, losartan etc. in bulk and dosage forms. These drugs are available in various combinations with Hydrochlorothiazide. This review is presenting various newly developed methods and their relevant data for the above mentioned drugs in combination with Hydrochlorothiazide.