Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2013 Vol: 5 Issue: 6

Determination of atazanavir sulfate in pharmaceutical dosage forms by extraction spectrophotometry using acid dyes


Three simple, accurate and sensitive extraction spectrophotometric methods (A, B and C) have been developed for the determination of atazanavir sulfate in its pharmaceutical dosage forms. The methods are based on extraction of colored ion-association complexes formed between Atazanavir sulfate and BTB, BPB and BCG in to chloroform in potassium hydrogen phthalate buffer (pH-2.4).The complexes show λmax at 414nm, 410nm and 417nm respectively. Beer’s law is obeyed in the concentration range 2-14μgmL-1 of atazanavir sulfate for methods A and B and in the range 2-12 μgmL-1 for method C. Results of analysis for all the methods are validated statistically and by recovery studies. The proposed methods are economical, sensitive and can be used for routine analysis of atazanavir sulfate in bulk and pharmaceutical formulations.

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