Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2015 Vol: 7 Issue: 6

Designing and synthesis of biologically active naturaloctapeptide, polycarponin B and itsanalog

Abstract

The present study describes designing of Polycarponin B and its N-methylated analog by retrosynthetic analysis. Synthesis of the titled compounds was then carried out by solution phase technique. The structure of the synthesized compounds was confirmed by IR, 1H NMR, 13C NMR, Mass and elemental analysis. The compounds were evaluated for antimicrobial, antifungal and antioxidant activity. From the results of biological activity it was concluded that newly synthesized compound possessed very good activity against Gram positive bacteria and moderate activity against Gram negative bacteria and pathogenic fungi. The N-methylated analog of Polycarponin B showed increase in the antimicrobial and antioxidant activity in comparison with Polycarponin B.