Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2015 Vol: 7 Issue: 7

Design, synthesis and biological evaluation of novel diphenylthiazole-thiazolidin-4-one-based derivatives as anti-inflammatory/analgesic agents


A series of novel diphenylthiazole-thiazolidin-4-one-based derivatives was synthesized and characterized by elemental and spectral analysis. The newly synthesized compounds were screened for their analgesic and anti-inflammatory activities using acetic acid-induced writhing test and carrageenan-induced edema assay, respectively. Among the compounds, compound 13 was found to be the most potent analgesic and anti-inflammatory agent among the newly synthesized compounds compared to the standard drug, diclofenac.