Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2015 Vol: 7 Issue: 8

Design, synthesis, and biological evaluation of novel 3-(arylsulfonamido) phenyloxiindole derivatives as TNF-�Ž�± and IL-6 inhibitor

Abstract

A series of novel (3-sulfonamido) phenyloxindoles were prepared from (3H-indene-1,2-dione) isatin via reductive amination, reduction followed by reaction of resulting amine with different arenesulfonyl chloride and screened for their Proinflammatory cytokines inhibition (TNF-α and IL-6) on lipopolysaccharide stimulated peripheral blood mononuclear cells. The sulfonamide derivative such as compound 5d, 5h and 5i exhibited promising inhibition of the release of two cytokines TNF-α and IL-6 with IC-50 values raging over 1.9-2.6 and 1.2-1.7 respectively and thus proved to be potent TNF-α and IL-6 inhibitor.