Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

header
Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2010 Vol: 2 Issue: 1

Design, synthesis and biological evaluation of benzoxazole derivatives as new antiinflammatory agents

Abstract

New series of methyl 2-(arylideneamino) benzoxazole -5-carboxylate derivatives were synthesized by the reaction of Schiff bases of meth yl 2-aminobenzoxazole-5-carboxylate with appropriate aromatic aldehydes. The chemical struct ures of the synthesized compounds were confirmed by means of IR, 1HNMR, mass spectral anal ysis. Further, the synthesized compounds (SH1-SH9) were screened for antiinflammatory activi ty by using Carrageenan – induced paw edema rat model. The results showed that, compounds SH1-SH3 and SH6-SH8 were significantly (p<0.0001) reduced the inflammation there by showed a promising antiinflammatory activity; where as the compound SH5 moderately reduced the in flammation. Only the two compounds i.e SH4 and SH9 showed very poor anti-inflammatory acti vity towards Carrageenan – induced paw edema rat.