Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

Reach Us reach to JOCPR whatsapp-JOCPR +44 1625708989
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Original Articles: 2019 Vol: 11 Issue: 1

Design, Synthesis and Antimicrobial Evaluation of Indolyl Pyrimidine Derivatives


The reaction of N-cyclopentyl-indole-3-carboxaldehydes with substituted acetophenones in ethanol and KOH as a base gives N-cyclopentylindolylchalcones [3a-3l]. Which on treatment with urea in presence of base resulted in the cyclization of α, β-unsaturated ketone into the substituted pyrimidines [4a-4l] with goodyield after purification. The synthesized compounds were characterised by 1H-NMR, IR and Mass and screened for their Anti-microbial activity.

rtp slot demo