Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Original Articles: 2010 Vol: 2 Issue: 4

Design of fast dissolving tablets of Chlorthalidone using novel coprocessed superdisintegrants

Abstract

In the present work, fast dissolving tablets of Chlorthalidone were prepared using novel coprocessed superdisintegrants consisting of crospovidone and croscarmellose sodium in the different ratios (1:1, 1:2 and 1:3). Chlorthalidone is widely accepted for its excellent antihypertensive and anti-diuretic effect. Effect of co-processed superdisintegrants on wetting time, disintegrating time, drug content, and in-vitro release have been studied. Drug compatibility with excipients was checked by FTIR and DSC studies. Stability studies were carried out as per ICH guidelines for three months. The values of pre-compression parameters evaluated were within prescribed limits and indicated good free flowing property. In all the formulations, hardness test indicated good mechanical strength results were ranges from 2.96 to 3.24 kg/cm2, friability is less than 1%, indicated that tablets had a good mechanical resistance. Thickness of the tablets range from 2.11 to 2.21 mm. Drug content was found to be in the range of 98.10 to 99.88 %. The wetting time is an important criteria for understanding the capacity of disintegrants to swell in presence of little amount of water were found to be in the range of 24 to 124 sec. Among all the designed formulations, formulation CP1 was found to be promising and was displayed an in-vitro dispersion time of 19 sec, which facilitates its faster dispersion in the mouth. Among all the formulations CP1 containing 4% w/w of co-processed superdisintegrants was found to be promising and has shown an in-vitro dispersion time of 19 sec, wetting time of 24 sec. Stability studies on promising formulation indicated that there were no significant changes in drug content and in-vitro dispersion time (p<0.05). From this study, it can be concluded that dissolution rate of Chlorthalidone could be enhanced by tablets containing coprocessed superdisintegrant.