In Present work, orally disintegrating tablets of Prochlorperazine maleate were design with a view to enhance Patient compliance by direct compression method. In this method sodium starch glycolate, crospovidone and croscarmellose sodium use as superdisintegrant (2-8% w/w) along with microcrystalline cellulose (pH 102), directly compressible lactose (DCL-11) and sodium Saccharin to enhance mouth feel. The prepared batches of tablet were evaluated for hardness, friability, content uniformity, wetting time, water absorption ratio and in vitro dispersion time. Based on in vitro dispersion time (Approximately 21 to 30 s), two promising formulation were tested for in vitro drug release pattern in pH 6.8 phosphate buffer. Among the two promising formulation, the formulation containing 8% sodium starch glycolate and 8% crospovidone emerged as the overall best formulation (t50% 8-10 min) based on drug release characteristic in pH 6.8 phosphate buffer compared to commercial conventional tablet formulation (t50% 22-25 min). Short-term stability studies on the promising formulations indicate that there are no significant changes in drug content and in vitro dispersion time.