Original Articles: 2010 Vol: 2 Issue: 4
Design and in vitro evaluation of drug release and bio adhesive properties from bucoadhesive tablets of Glibenclamide for systemic delivery
The buccal route has been used for many years to delivery drug which undergoes first pass metabolism within the oral mucosal cavity, the buccal region often attractive route of administration for local or systemic drug delivery. Due to its high potential a bioadhesive system place a major role in controlling drug release. Recent interest has been expressed in the delivery of drug via mucus membrane by the use of adhesive materials on which studies are been intensively undertaken. The objective of this work was to design a mucoadhesive tablet with a potential use in the treatment of Diabetes mellitus. A Bi-layered tablet (Core layered + Backing layered) containing Glibenclamide has been formulated. Carbopol-940, Polyvinylpyrrolidone (PVP), and Sodium corboxymethyl cellulose were used as polymer. Tablets were obtained through direct compression. Properties such as in vitro mucoadhesion, water uptake, surface pH, and drug release were evaluated. The core layer constituents were Glibenclamide (5mg), Carbopol, Na-CMC and PVP in 3 different ratios. The backing layer does not contain drug, it is meant to prevent tablet from disintegration in buccal cavity. The mixture CP: Na-CMC (2:3) showed good water absorption. The CP : PVP (1:4) formulations(F5) showed the best drug release pattern and bioadhesion property. The analysis of in vitro release data showed zero.