The novel approach of using a transdermal drug delivery system through intact skin has time again been recognized as a important mode of administration of several systemically active drugs. Many drugs with short biological half-life and prone to first pass effect are reported to be good candidates for transdermal drug delivery. In recent years, crescendo of transder material, is encouraging. Therefore, in this work an attempt is made in developing transdermal patches of HPMC containing Keterolac for extended duration of action. This work is aimed at studying the release profiles of Keterolac , from HPMC matrix. The effect of various co-polymers, Cellulose acetate & Ethyl cellulose, each in different promal drug delivery has fallen to best of its share, in using hydrophillic polymer matrix containing drug, because of its patient compliance and avoidance of first pass metabolism. Keterolac tromethamine is a non-steroidal anti-inflammatory drug, reported to be potent analgesic and anti-inflammatory agent, has a short biological half life of 4-6 hrs. In this work, Keterolac is chosen as a suitable drug candidate to explore its potentiality in being delivered through skin. Previous research on HPMC, a hydrophillic, polymeric matrix portions 8:1, 4:1, 2:1 and 1:1 of HPMC (w/w) and the effect of different plasticizers/penetrating enhancers like, glycerol and DBP both in 20%, 30% & 40% w/w of HPMC, on the physical characteristics & In-vitro release profiles will be studied. Further, Pharmaco dynamic studies on suitable patches will be conducted. Also, stability studies at different temperatures and %RH will be undertaken.