Journal of Chemical and Pharmaceutical Research (ISSN : 0975-7384)

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Reviews: 2009 Vol: 1 Issue: 1

Darling's Disease: A Review

Abstract

Histoplasmosis is primarily a pulmonary disease caused by the fungus Histoplasma capsulatumwith varying symptoms.The fungus is found in high concentrations in soil contaminated withbird or bat excreta while transmission occurs via inhalation of H. capsulatum spores from the soil. The fungal infection either is cleared or the organism continues to reproduce intracellularly and disseminates throughout the body via lymphatic and hematogenous circulation. Darling, a world-leading pathologist discovered Histoplasmosis to be a fungal infection in 1905 therefore it is also called as Darling’s disease. Transmission occurs in areas like caves containing bat or bird droppings, chicken coops, birdhouses, bird roosts, or soil contaminated with such droppings. H.capsulatum can survive in soil for years and if the soil becomes airborne, it may cause Histoplasmosis. In patients that are immunosuppressed, complications are mouth ulcers, fevers,headaches, confusion, seizures, encephalopathy and infrequently, death.

Histoplasmosis is primarily a pulmonary disease caused by the fungus Histoplasma capsulatumwith varying symptoms.The fungus is found in high concentrations in soil contaminated withbird or bat excreta while transmission occurs via inhalation of H. capsulatum spores from the soil. The fungal infection either is cleared or the organism continues to reproduce intracellularly and disseminates throughout the body via lymphatic and hematogenous circulation. Darling, a world-leading pathologist discovered Histoplasmosis to be a fungal infection in 1905 therefore it is also called as Darling’s disease. Transmission occurs in areas like caves containing bat or bird droppings, chicken coops, birdhouses, bird roosts, or soil contaminated with such droppings. H.capsulatum can survive in soil for years and if the soil becomes airborne, it may cause Histoplasmosis. In patients that are immunosuppressed, complications are mouth ulcers, fevers,headaches, confusion, seizures, encephalopathy and infrequently, death.